Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP) -specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of (cGMP), which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of (cGMP) degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.
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