UDCA Biocatalyst – 7α/7β-HSDH + LDH/GDH Cascade API Manufacturers & Suppliers
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Looking for UDCA Biocatalyst – 7α/7β-HSDH + LDH/GDH Cascade API ?
- Description:
- Here you will find a list of producers, manufacturers and distributors of UDCA Biocatalyst – 7α/7β-HSDH + LDH/GDH Cascade. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- UDCA Biocatalyst – 7α/7β-HSDH + LDH/GDH Cascade
- Synonyms:
- 7a -HSDH\LDH\7β -HSDH\GDH
This recombinant whole-cell biocatalyst expresses a four-enzyme cascade — 7α-HSDH, 7β-HSDH, LDH, and GDH — for the efficient biotransformation of chenodeoxycholic acid (CDCA) into ursodeoxycholic acid (UDCA) or tauroursodeoxycholic acid (TUDCA). Developed using E. coli, the system enables high-yield enzymatic conversion (>98%) with in vivo cofactor regeneration, eliminating the need for external NAD(P)H.
The cascade includes:
7α-HSDH: Oxidizes CDCA to 7-keto-LCA
7β-HSDH: Reduces 7-keto-LCA to UDCA
LDH & GDH: Regenerate NAD⁺ and NADPH for continuous enzyme cycling
This scalable platform is ideal for pharmaceutical manufacturers, CDMOs, and research teams working on bile acid derivatives, steroid APIs, or sustainable biocatalysis. Available as a live recombinant strain or lysate.