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Methotrexatum (Methotrexate)
API Manufacturers & Suppliers
Pakistan
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Engaged in the production of small molecule chemical drug APIs and preparations
Provide CDMO services for high-activity anti-tumor characteristic APIs
153-acre API and preparation production base
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Producer
Produced in:
Established in: 2021
MOQ: -
Employees: 19
API, Intermediates, Building Blocks, Impurities, Amino acids and Peptides
Small quantity APIs to commercial scale
GMP and USFDA certification based on quantity, order, assignment.
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Produced in:
Established in: 1994
MOQ: -
Employees: 50+
26+ years of distribution expertise with regulatory excellence
16 worldwide locations supplying high quality ingredients
All our manufacturer partners are cGMP complaint
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Produced in:
Established in: 2012
MOQ: 1 kg
Employees: 50+
Diverse portfolio of APIs and Nutra products
Focus on Hormones Oncology and Peptides with the highest quality
Leading manufacturer of ALpha Lipoic Acid
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Looking for Methotrexate API 59-05-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Methotrexate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Methotrexate
- Synonyms:
- Amethopterin , Emtexate , Ledertrexate , Methotrexat , Methotrexatum , Metotrexato , MTX , Rheumatrex , Trexall
- Cas Number:
- 59-05-2
- DrugBank number:
- DB00563
- Unique Ingredient Identifier:
- YL5FZ2Y5U1
About Methotrexate
Why are people looking for Methotrexate? Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments.
You can ask the supplier about all relevant certificates for the product such as CoA, Safety Data Sheet and DMF.
Methotrexate is a type of Antimetabolites
Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.
One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.
Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.
Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.
In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.
Methotrexate manufacturers | traders | suppliers
We have 13 companies offering Methotrexate produced in 5 different countries.
Get in contact with the supplier of your choice:
- Sichuan Elixir Pharmaceutical Co., Ltd from China, product country of origin China
- SETV Global from India, product country of origin India
- Rochem International, Inc. from United States, product country of origin United States
- Mac Chem Products from India, product country of origin India
- Suryakala Laboratories Pvt Ltd from India, product country of origin India
- Zhejiang Hisun Pharma from China, product country of origin China
- Patriapharma from Hungary, product country of origin Hungary
- Avanscure Lifesciences Pvt Ltd from India, product country of origin India
- Huzhou Zhanwang from China, product country of origin China
- Zhejiang Haizhou from China, product country of origin China
- CF Pharma from Hungary, product country of origin Hungary
- Shanghai Jinhe Bio-Pharma from China, product country of origin China
- Fermion from Finland, product country of origin Finland
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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