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Pemetrexed disodium heptahydrate (Pemetrexed) API Manufacturers & Suppliers

Looking for Pemetrexed API 137281-23-3?

Description:

Here you will find a list of producers, manufacturers and distributors of Pemetrexed. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Pemetrexed 

Synonyms:

Pemetrexed disodium heptahydrate  

Cas Number:

137281-23-3 

DrugBank number:

DB00642 

Unique Ingredient Identifier:

04Q9AIZ7NO

Pemetrexed is a type of Antimetabolites

Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.

One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.

Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.

Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.

In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.

• Sinoway industrial Co.,Ltd from China, product country of origin China
• Shilpa Medicare Ltd from India, product country of origin India
• Gonane Pharma from India, product country of origin India
• Shandong Boyuan from China, product country of origin China
• Apino Pharma Co., Ltd. from China, product country of origin China
• Nippon Kayaku from Japan, product country of origin Japan
• Wuhan Calmland  from China, product country of origin China
• Shanghai Jinhe Bio-Pharma from China, product country of origin China
• Polymed Therapeutics from United States, product country of origin United States
• Laurus Labs from India, product country of origin India
• Adley Formulations from India, product country of origin India
• Suzhou Lixin from China, product country of origin China
• Jiangsu Hansoh Pharma from China, product country of origin China
• Dr. Reddy's from India, product country of origin India
• Mac Chem Products from India, product country of origin India
• Chongqing Taihao from China, product country of origin China
• Reliance Life Sciences from India, product country of origin India
• Qilu Antibiotics from China, product country of origin China
• Huzhou Zhanwang from China, product country of origin China
• TIEFENBACHER API + Ingredients from Germany, product country of origin Unknown
• BrightGene from China, product country of origin China
• Acebright Pharma from India, product country of origin India
• Teva API from Israel, product country of origin Unknown
• Hetero Labs from India, product country of origin India
• Cipla from India, product country of origin India
• Emcure Pharma from India, product country of origin India
• MSN Labs. from India, product country of origin India
• Sun Pharma from India, product country of origin India
• Mylan from India, product country of origin India

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