Ceritinib | compare suppliers & send inquiries for free
MOQ: 0 kg
Suzhou Bichal Biological Technology
MOQ: 10 g
Looking for Ceritinib 1032900-25-6?
More information about this product: Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), which results in constitutive kinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype. Ceritinib exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells. Following treatment with crizotinib (a first-generation ALK inhibitor), most tumours develop drug resistance due to mutations in key gatekeeper residues of the enzyme.
This occurrence led to development of novel second-generation ALK inhibitors such as ceritinib to overcome crizotinib resistance. The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant tumours and has designated it with orphan drug status.
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Ceritinib manufacturers | traders | suppliers
We have 2 companies offering Ceritinib from 2 different countries.
Get in contact with the supplier of your choice:
- MSN Labs. from India
- Suzhou Bichal Biological Technology from China
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