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Established in: 2011
MOQ: -
Employees: 25
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Looking for Colestipol API 26658-42-4?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Colestipol. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Colestipol
- Synonyms:
- Colestipolum , Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane
- Cas Number:
- 26658-42-4
- DrugBank number:
- DB00375
- Unique Ingredient Identifier:
- K50N755924
About Colestipol
More information about this product: Bile acid sequestrants like colestipol have been in use since the 1970s.5 And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally only employed as an adjunct therapy and the relatively physical nature of its pharmacological activity sometimes limits its usefulness.5 In particular, as colestipol's general mechanism of action ultimately results in the decreased absorption and enhanced secretion of bile acids and lipids in the feces, patients who take complicated medication regimens, experience constipation or biliary obstruction, etc. may not be good candidates for using the agent owing to its physical effects on the gut.
Do you want to buy this product? Send an inquiry to the listed suppliers that meets your quality requirements.
Colestipol is a type of Bile acid sequestrants
Bile acid sequestrants belong to the pharmaceutical API subcategory of cholesterol-lowering agents. These agents are primarily used in the management of hypercholesterolemia and related cardiovascular conditions. Bile acid sequestrants function by binding to bile acids in the gastrointestinal tract, forming a complex that prevents their reabsorption. This mechanism promotes the excretion of bile acids in the feces and subsequently increases the hepatic conversion of cholesterol to bile acids, leading to a reduction in circulating cholesterol levels.
Bile acid sequestrants are commonly prescribed as adjunct therapy to statins or as an alternative for individuals who cannot tolerate statin therapy. They are typically administered orally in the form of powders, tablets, or granules, and they are not absorbed into the bloodstream. This characteristic makes them relatively safe, with a low risk of systemic side effects.
The main bile acid sequestrants used in clinical practice include cholestyramine, colesevelam, and colestipol. These agents have demonstrated efficacy in reducing low-density lipoprotein cholesterol (LDL-C) levels and improving lipid profiles. Additionally, they may have secondary benefits, such as improving glycemic control in patients with type 2 diabetes and reducing the risk of cardiovascular events.
Overall, bile acid sequestrants play a vital role in managing hypercholesterolemia and are an important component of cardiovascular disease management. With their cholesterol-lowering properties and favorable safety profile, they offer an effective therapeutic option for patients seeking to improve their lipid profiles and reduce their risk of cardiovascular complications.
Colestipol (Bile acid sequestrants), classified under Gastrointestinal Agents
Gastrointestinal Agents belong to the pharmaceutical API category that focuses on treating disorders and ailments related to the digestive system. These agents play a crucial role in addressing various gastrointestinal conditions, such as acid reflux, ulcers, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD).
One of the key types of gastrointestinal agents is proton pump inhibitors (PPIs), which work by reducing the production of stomach acid. PPIs help in treating conditions like gastroesophageal reflux disease (GERD) and peptic ulcers. Another essential class of agents is antacids, which neutralize excessive stomach acid, providing relief from heartburn and indigestion.
Gastrointestinal agents also include antispasmodics that alleviate abdominal cramps and spasms associated with conditions like IBS. These drugs work by relaxing the smooth muscles of the digestive tract. Additionally, there are drugs categorized as laxatives that aid in relieving constipation by promoting bowel movements.
Moreover, certain gastrointestinal agents act as antiemetics, effectively reducing nausea and vomiting. These drugs are particularly useful for patients undergoing chemotherapy or experiencing motion sickness.
Pharmaceutical companies develop and manufacture a wide range of gastrointestinal agents in various forms, including tablets, capsules, suspensions, and injections. These agents are typically formulated using active pharmaceutical ingredients (APIs) and other excipients to ensure their efficacy and safety.
In conclusion, gastrointestinal agents form a vital category of pharmaceutical APIs, providing relief from digestive disorders and improving overall gastrointestinal health. The availability of diverse agents catering to different conditions ensures that patients can receive targeted treatment for their specific gastrointestinal needs.
Colestipol manufacturers | traders | suppliers
We have 2 companies offering Colestipol produced in 0 different countries.
Get in contact with the supplier of your choice:
- Global Pharma Tek from India, product country of origin India
- Formosa Labs from Taiwan, product country of origin Taiwan
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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