Diltiazem | compare suppliers & send inquiries for free
Looking for Diltiazem 42399-41-7?
Here, you can find what Diltiazem is used for, in short. Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolarization.
Compared to dihydropyridine drugs, such as nifedipine, that preferentially act on vascular smooth muscle and verapamil that directly acts on the heart muscle, diltiazem displays an intermediate specificity to target both the cardiac and vascular smooth muscle. Being a potent vasodilator, diltiazem is used clinically as an antihypertensive, anti-arrhythmic, and as an anti-anginal agent 9 for the management of cardiovascular conditions such as hypertension, chronic stable angina, atrial fibrillation, atrial flutter. Apart from its main FDA-approved indications, diltiazem has also been used for numerous off-label indications, such as anal fissures (in topical formulations), migraine prophylaxis, pulmonary hypertension, and rest-related cramps in the lower extremities. Typically available in extended-release oral and intravenous formulations, diltiazem is marketed under various brand names with Cardizem and Tiazac being the most common ones.
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Diltiazem manufacturers | traders | suppliers
We have 15 companies offering Diltiazem from 5 different countries.
Get in contact with the supplier of your choice:
- Duchefa Farma B.V. from Netherlands
- TIEFENBACHER API + Ingredients from Germany
- Fermion from Finland
- Chemeca Drugs pvt Ltd from India
- Divis Labs. from India
- Piramal Pharma Solutions from India
- Fabbrica Italiana Sintetici (FIS) from Italy
- Dr. Reddy's from India
- Teva from Israel
- Teva Pharma ind. from Israel
- Teva India from Israel
- Lusochimica from Italy
- Synthelabo T.C. from France
- Cambrex from Italy
- Spansules Pharmatech Pvt Ltd from India
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