Lactitol API Manufacturers

General Description:

Lactitol, identified by CAS number 585-86-4, is a notable compound with significant therapeutic applications. Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from . It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. ). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as , in the treatment of hepatic encephalopathy in patients with cirrhosis. Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.

Indications:

This drug is primarily indicated for: Lactitol is indicated for the treatment of chronic idiopathic constipation in adults. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Lactitol undergoes metabolic processing primarily in: As it undergoes little-to-no systemic absorption, lactitol is unlikely to undergo any significant degree of metabolism. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Lactitol are crucial for its therapeutic efficacy: In healthy subjects under fed conditions, oral administration of 20 grams of lactitol resulted in a mean T_max of 3.6 ± 1.2 hours, C_max of 776 ± 253 ng/mL, and a mean AUC of 6,019 ± 1,771 ng*hr/mL. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Lactitol is an important consideration for its dosing schedule: The average half-life of orally administered lactitol is 2.4 hours. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Lactitol exhibits a strong affinity for binding with plasma proteins: As it undergoes little-to-no systemic absorption, lactitol is unlikely to be subject to protein binding. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Lactitol from the body primarily occurs through: Lactitol is not absorbed in the gastrointestinal tract to any significant extent. The vast majority of an ingested dose is likely degraded into organic acids in the colon and eliminated in the feces. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Lactitol is distributed throughout the body with a volume of distribution of: Data regarding the volume of distribution of lactitol are unavailable. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Lactitol is a critical factor in determining its safe and effective dosage: Data regarding the clearance of lactitol are unavailable. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Lactitol exerts its therapeutic effects through: Lactitol helps to facilitate bowel movements by drawing water into the gastrointestinal tract. The oral administration of lactitol may reduce the absorption of concomitant medications - other oral medications should be administered at least 2 hours before or 2 hours after lactitol. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Lactitol functions by: Lactitol is an osmotic laxative - it exerts its pharmacologic effect by creating a hyperosmotic environment within the small intestine. The osmotic effect generated by lactitol draws water into the small intestine, which loosens stools and ultimately facilitates bowel movements. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Lactitol belongs to the class of organic compounds known as fatty acyl glycosides of mono- and disaccharides. These are compounds composed of a mono- or disaccharide moiety linked to one hydroxyl group of a fatty alcohol or of a phosphorylated alcohol (phosphoprenols), a hydroxy fatty acid or to one carboxyl group of a fatty acid (ester linkage) or to an amino alcohol, classified under the direct parent group Fatty acyl glycosides of mono- and disaccharides. This compound is a part of the Organic compounds, falling under the Lipids and lipid-like molecules superclass, and categorized within the Fatty Acyls class, specifically within the Fatty acyl glycosides subclass.

Categories:

Lactitol is categorized under the following therapeutic classes: Alcohols, Alimentary Tract and Metabolism, Carbohydrates, Compounds used in a research, industrial, or household setting, Diet, Food, and Nutrition, Drugs for Constipation, Flavoring Agents, Food, Food Additives, Food Ingredients, Gastrointestinal Agents, Laxatives, Osmotic Activity, Osmotic Laxatives, Pharmaceutic Aids, Pharmaceutical Preparations, Stimulation Small Intestine Fluid/Electrolyte Secretion, Sweetening Agents. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.