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Idelalisib | compare suppliers & send inquiries for free

Here you will find a list of producers, manufacturers and traders of Idelalisib. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
Lupin


Type: Producer
Origin: India
India
Zhejiang Neo-Dankong


Type: Producer
Origin: China
China
Changzhou Truly Foreign Trade

MOQ: 1 kg
Type: Trader
Origin: China
China

Looking for Idelalisib 870281-82-6?

API | Excipient name:
Idelalisib 
Synonyms:
 
Cas Number:
870281-82-6 
DrugBank number:
DB09054 
Unique Ingredient Identifier:
YG57I8T5M0

About Idelalisib

More information about the use of: Idelalisib. Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies. More specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4-bisphosphate 3-kinase, also known as PI-3K.

The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils. By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and adhesion, and reduced cell viability.

You can ask the supplier about all relevant certificates for the product such as CoA, Safety Data Sheet and DMF.

Idelalisib manufacturers | traders | suppliers
We have 3 companies offering Idelalisib from 2 different countries.

Get in contact with the supplier of your choice:

  • Lupin from India
  • Changzhou Truly Foreign Trade from China
  • Zhejiang Neo-Dankong from China

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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