Lenvatinib | compare suppliers & send inquiries for free
Looking for Lenvatinib 417716-92-8?
Here you will find more information about Lenvatinib. Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, and 4; the platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. These receptor tyrosine kinases (RTKs) located in the cell membrane play a central role in the activation of signal transduction pathways involved in the normal regulation of cellular processes, such as cell proliferation, migration, apoptosis and differentiation, and in pathogenic angiogenesis, lymphogenesis, tumour growth and cancer progression.
In particular, VEGF has been identified as a crucial regulator of both physiologic and pathologic angiogenesis and increased expression of VEGF is associated with a poor prognosis in many types of cancers. Lenvatinib is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine (RAI)-refractory differentiated thyroid cancer. Most patients with thyroid cancer have a very good prognosis with treatment (98% 5 year survival rate) involving surgery and hormone therapy. However, for patients with RAI-refractory thyroid cancer, treatment options are limited and the prognosis is poor, leading to a push for the development of more targeted therapies such as lenvatinib.
Ask the supplier for a certificate of analysis to find out more about the quality of Lenvatinib.
Lenvatinib manufacturers | traders | suppliers
We have 7 companies offering Lenvatinib from 3 different countries.
Get in contact with the supplier of your choice:
- Shandong Octagon Chemicals Limited from China
- Apino Pharma Co., Ltd. from China
- R&S Chemicals from United States
- SENOVA Technology Co., Ltd. from China
- Shilpa Medicare from India
- Beijing Mesochem Technology Co Ltd from China
- Hunan Ouya Biological Co., Ltd. from China
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