Methotrexate API Manufacturers & Suppliers

Looking for Methotrexate API 59-05-2?

Description:

Here you will find a list of producers, manufacturers and distributors of Methotrexate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Methotrexate 

Synonyms:

Amethopterin , Emtexate , Ledertrexate , Methotrexat , Methotrexatum , Metotrexato , MTX , Rheumatrex , Trexall  

Cas Number:

59-05-2 

DrugBank number:

DB00563 

Unique Ingredient Identifier:

YL5FZ2Y5U1

Methotrexate is a type of Antimetabolites

Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.

One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.

Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.

Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.

In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.

• Sichuan Elixir Pharmaceutical Co., Ltd from China, product country of origin China
• SETV Global from India, product country of origin India
• Rochem International, Inc. from United States, product country of origin United States
• Zhejiang Haizhou from China, product country of origin China
• Huzhou Zhanwang from China, product country of origin China
• Suryakala Laboratories Pvt Ltd from India, product country of origin India
• Mac Chem Products from India, product country of origin India
• Patriapharma from Hungary, product country of origin Hungary
• Zhejiang Hisun Pharma from China, product country of origin China
• CF Pharma from Hungary, product country of origin Hungary
• Shanghai Jinhe Bio-Pharma from China, product country of origin China
• Fermion from Finland, product country of origin Finland

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