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Indometacine (Indomethacin)
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Distributor
Produced in:
Established in: 1885
MOQ: -
Employees: 150
Trusted for 140 years
Global distribution business with API manufacturing facilities
European company with presence in 3 continents
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Producer
Produced in:
Established in: 2021
MOQ: -
Employees: 19
API, Intermediates, Building Blocks, Impurities, Amino acids and Peptides
Small quantity APIs to commercial scale
GMP and USFDA certification based on quantity, order, assignment.
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Distributor
Produced in:
Established in: 2005
MOQ: -
Employees: 200+
Portfolio of over 2,000 APIs
Precise quality control
End-to-end global regulatory support
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Producer
Produced in:
Established in: 2011
MOQ: 25 kg
Employees: 10+
Fast Response and Good Communication
Willingness To Start From Small
Flexible Payment Terms
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Distributor
Produced in:
Established in: 2019
MOQ: -
Employees: 50+
ISO 9001, SGS, Certificated supplier.
Audit available either on site or remote.
Professional One Stop Service for delivery to customers.
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Distributor
Produced in:
Established in: 2007
MOQ: -
Employees: 200+
GMP, WC, CEP, FDA, ISO Certificate
Arshine Group supplies more than 2,000 kinds of products
Arshine's marketing network has spread over more than 100 countries
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Looking for Indomethacin API 53-86-1?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Indomethacin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Indomethacin
- Synonyms:
- Aconip , Indocin , Indometacin , Indometacina , Indometacine , Indometacinum , Indomethacin , Indometacin
- Cas Number:
- 53-86-1
- DrugBank number:
- DB00328
- Unique Ingredient Identifier:
- XXE1CET956
About Indomethacin
Learn more about Indomethacin. Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated;the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid. The pharmacological effect of indometacin is not fully understood, however, it is thought to be mediated through potent and nonselective inhibition of the enzyme cyclooxygenase (COX), which is the main enzyme responsible for catalyzes the rate-limiting step in prostaglandin and thromboxane biosynthesis via the arachidonic acid (AA) pathway.
Indometacin was first discovered in 1963 and it was first approved for use in the USA by the Food and Drug Administration in 1965, 10 along with other acetic acid derivatives such as diclofenac and sulindac that were also developed during the 1960s. Since then, indometacin has been extensively studied in clinical trials as one of the most potent NSAIDs in blocking prostaglandin synthesis and was among the first NSAIDs to be used in the symptomatic treatment of migraine and for headaches that eventually became known as “indomethacin-responsive” headache disorders. Most commonly used in rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis, indometacin is currently available as oral capsules as well as other methods of administration, including rectal and intravenous formulations. Intravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants.
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Indomethacin is a type of NSAIDs
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are a widely used subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs). These medications are commonly prescribed for their analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties. NSAIDs work by inhibiting the production of certain enzymes called cyclooxygenases (COX), which play a crucial role in the synthesis of prostaglandins, substances that contribute to pain, inflammation, and fever.
These pharmaceutical APIs are available in various formulations, including tablets, capsules, creams, and gels, making them convenient for different administration routes. Some popular examples of NSAIDs include aspirin, ibuprofen, naproxen, and diclofenac.
NSAIDs are commonly used to treat a wide range of conditions such as arthritis, musculoskeletal injuries, dental pain, menstrual pain, and headaches. They are also effective in managing inflammatory conditions like rheumatoid arthritis and ankylosing spondylitis.
While NSAIDs are generally safe and effective when used as directed, they may have side effects. These can include gastrointestinal issues such as stomach ulcers or bleeding, cardiovascular risks, and kidney problems. Therefore, it is essential to follow the recommended dosage and consult with healthcare professionals to ensure proper and safe usage.
In conclusion, NSAIDs are a subcategory of pharmaceutical APIs that offer analgesic, anti-inflammatory, and antipyretic properties. Their versatility and effectiveness in treating various conditions make them widely prescribed medications. However, it is crucial to be aware of potential side effects and consult healthcare providers for appropriate usage.
Indomethacin (NSAIDs), classified under Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
Indomethacin manufacturers | traders | suppliers
We have 13 companies offering Indomethacin produced in 6 different countries.
Get in contact with the supplier of your choice:
- Chr. Olesen Group from Denmark, product country of origin Unknown
- SETV Global from India, product country of origin India
- LGM Pharma from United States, product country of origin World
- Shandong Octagon Chemicals Limited from China, product country of origin China
- Aurora Industry Co., Ltd from China, product country of origin China
- Arshine Pharmaceutical Co., Limited from China, product country of origin China
- Sogo Pharmaceutical from Japan, product country of origin Japan
- Lundbeck Pharma from Italy, product country of origin Italy
- ACE Japan from Japan, product country of origin Japan
- CSPC Ouyi Pharma from China, product country of origin China
- Taicang Pharmaceutical Factory from China, product country of origin China
- Quimdis from France, product country of origin Unknown
- Shaoxing Hantai Pharma from China, product country of origin China
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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