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What makes Raloxifene unique? Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation Exhibiting tissue-specific effects distinct from estradiol, raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM. Available in many countries worldwide, raloxifene was initially approved by the FDA in December, 1997 under the market name Evista® for the management and prevention of osteoporosis in postmenopausal women and reduction in risk for invasive breast cancer in postmenopausal women with osteoporosis or those who are at high risk for invasive breast cancer. However, it has a negligible effect on altering the development and progression of breast cancer itself. The most common causes of osteoporosis include postmenopausal deficiency of estrogen and age-related deterioration in bone homeostasis.
Due to the risk of bone fractures that may lead to morbidities and reduced quality of life, the management of osteoporosis in postmenopausal women with the use of therapeutic agents in addition to concurrent therapies is critical. Due to the decline in estrogen levels in postmenopausal osteoporosis, hormone replacement therapy (HRT), such as estradiol, has been used to ameliorate the condition. However, due to the off-target actions by HRT, newer non-hormonal agents such as raloxifene and tamoxifen have been developed to reduce adverse events through selective pharmacological actions on tissue-specific therapeutic targets. The main effects of raloxifene are to preserve the bone mineral density and decrease the risk of breast cancer in postmenopausal women. Compared to estrogen and tamoxifen, raloxifene was not associated with an increased risk of uterine cancer and it does not cause endometrial proliferation.
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Raloxifene manufacturers | traders | suppliers
We have 17 companies offering Raloxifene from 4 different countries.
Get in contact with the supplier of your choice:
- Hetero Drugs from India
- omicron pharma from India
- Aarti Drugs from India
- Erregierre from Italy
- Aurobindo from India
- Apotex Pharmachem from India
- Dr. Reddy's from India
- Cadila Pharma from India
- Olon from Italy
- Teva API from Israel
- Torrent Pharma from India
- Glochem from India
- Cambrex from Italy
- Cipla from India
- Raks Pharma from India
- Hanmi Fine Chemical from South Korea
- Sai-Tech Pharmaceuticals Pvt. Ltd. from India
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