Rosiglitazone | compare suppliers & send inquiries for free
Looking for Rosiglitazone 122320-73-4?
Here, you can find what Rosiglitazone is used for, in short. Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GSK as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ.
Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Rosiglitazone manufacturers | traders | suppliers
We have 5 companies offering Rosiglitazone from 3 different countries.
Get in contact with the supplier of your choice:
- SMS Pharma from India
- Dr. Reddy's from India
- Teva from Israel
- Chemsynlab from China
- Zhejiang Chemsyn from China
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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