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    Sacubitril | compare suppliers & send inquiries for free

    Here you will find a list of producers, manufacturers and traders of Sacubitril. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
    China Zhejiang Tianyu
    Type: Producer
    Produced in: China
    China
    China Zhejiang Hongyuan
    Type: Producer
    Produced in: China
    China
    India Lupin
    Type: Producer
    Produced in: India
    India
    Germany TIEFENBACHER API + Ingredients
    Type: Distributor
    Produced in: Germany
    Unknown
    Why TIEFENBACHER API ?
    China Shandong Octagon Chemicals Limited

    MOQ: 10 g
    Type: Distributor
    Produced in: China
    China
    India Raks Pharma
    Type: Producer
    Produced in: India
    India
    India Mylan
    Type: Producer
    Produced in: India
    India
    India MSN Life Sciences
    Type: Producer
    Produced in: India
    India

    Looking for Sacubitril 149709-62-6?

    API | Excipient name:
    Sacubitril 
    Synonyms:
     
    Cas Number:
    149709-62-6 
    DrugBank number:
    DB09292 
    Unique Ingredient Identifier:
    17ERJ0MKGI

    About Sacubitril

    It's time for some technical information for the ones who understand chemistry: Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It was approved by the FDA after being given the status of priority review for on July 2015. Sacubitril's active metabolite, LBQ657 inhibits neprilysin, a neutral endopeptidase that would typically cleave natiuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP). ANP and BNP are released under atrial and ventricle stress, which activate downstream receptors leading to vasodilation, natriuresis and diuresis.

    Under normal conditions, neprilysin breaks down other vasodilating peptides and also vasoconstrictors such as angiotensin I and II, endothelin-1 and peptide amyloid beta-protein. Inhibition of neprilysin therefore leads to reduced breakdown and increased concentration of endogenous natriuretic peptides in addition to increased levels of vasoconstricting hormones such as angiotensin II.

    Ask the supplier for a certificate of analysis to find out more about the quality of Sacubitril.

    Sacubitril manufacturers | traders | suppliers
    We have 8 companies offering Sacubitril from 3 different countries.

    Get in contact with the supplier of your choice:

    • Shandong Octagon Chemicals Limited from China
    • TIEFENBACHER API + Ingredients from Germany
    • Lupin from India
    • Zhejiang Tianyu from China
    • Mylan from India
    • Zhejiang Hongyuan from China
    • MSN Life Sciences from India
    • Raks Pharma from India

    Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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