Sacubitril | compare suppliers & send inquiries for free

Here you will find a list of producers, manufacturers and traders of Sacubitril. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

		GMP	CEP	WC	FDA	DMF	Available for download Document available for download after approval of supplier Set as available by supplier but document not uploaded yet
TIEFENBACHER API + Ingredients Type: Distributor Produced in: Germany	Distributor		−	−	−	−	+ 1	Send inquiry Replies quickly
Zhejiang Tianyu Type: Producer Produced in: China	Producer	−	−	−	−		+ 0	Send inquiry Replies slower than most
Zhejiang Hongyuan Type: Producer Produced in: China	Producer	−	−	−	−	−	+ 0	Send inquiry Replies slower than most
Lupin Type: Producer Produced in: India	Producer	−	−	−	−		+ 0	Send inquiry Replies slower than most
Shandong Octagon Chemicals Limited MOQ: 10 g Type: Distributor Produced in: China	MOQ: 10 g Distributor	−	−	−	−	−	+ 2	Send inquiry Replies in a day or 2
Raks Pharma Type: Producer Produced in: India	Producer	−	−	−	−		+ 0	Send inquiry Replies slower than most
Mylan Type: Producer Produced in: India	Producer	−	−	−	−		+ 0	Send inquiry Not active
MSN Life Sciences Type: Producer Produced in: India	Producer	−	−	−	−		+ 0	Send inquiry Not active

Looking for Sacubitril 149709-62-6?

API | Excipient name:: Sacubitril
Synonyms:
Cas Number:: 149709-62-6
DrugBank number:: DB09292
Unique Ingredient Identifier:: 17ERJ0MKGI

About Sacubitril

It's time for some technical information for the ones who understand chemistry: Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It was approved by the FDA after being given the status of priority review for on July 2015. Sacubitril's active metabolite, LBQ657 inhibits neprilysin, a neutral endopeptidase that would typically cleave natiuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP). ANP and BNP are released under atrial and ventricle stress, which activate downstream receptors leading to vasodilation, natriuresis and diuresis.

Under normal conditions, neprilysin breaks down other vasodilating peptides and also vasoconstrictors such as angiotensin I and II, endothelin-1 and peptide amyloid beta-protein. Inhibition of neprilysin therefore leads to reduced breakdown and increased concentration of endogenous natriuretic peptides in addition to increased levels of vasoconstricting hormones such as angiotensin II.

Ask the supplier for a certificate of analysis to find out more about the quality of Sacubitril.

Sacubitril manufacturers | traders | suppliers
We have 8 companies offering Sacubitril from 3 different countries.

Get in contact with the supplier of your choice:

Shandong Octagon Chemicals Limited from China
TIEFENBACHER API + Ingredients from Germany
Lupin from India
Zhejiang Tianyu from China
Mylan from India
Zhejiang Hongyuan from China
MSN Life Sciences from India
Raks Pharma from India

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