Sacubitril
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Looking for Sacubitril 149709-62-6?
- API | Excipient name:
- Sacubitril
- Synonyms:
- Cas Number:
- 149709-62-6
- DrugBank number:
- DB09292
- Unique Ingredient Identifier:
- 17ERJ0MKGI
About Sacubitril
It's time for some technical information for the ones who understand chemistry: Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It was approved by the FDA after being given the status of priority review for on July 2015. Sacubitril's active metabolite, LBQ657 inhibits neprilysin, a neutral endopeptidase that would typically cleave natiuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP). ANP and BNP are released under atrial and ventricle stress, which activate downstream receptors leading to vasodilation, natriuresis and diuresis.
Under normal conditions, neprilysin breaks down other vasodilating peptides and also vasoconstrictors such as angiotensin I and II, endothelin-1 and peptide amyloid beta-protein. Inhibition of neprilysin therefore leads to reduced breakdown and increased concentration of endogenous natriuretic peptides in addition to increased levels of vasoconstricting hormones such as angiotensin II.
Ask the supplier for a certificate of analysis to find out more about the quality of Sacubitril.
Sacubitril manufacturers | traders | suppliers
We have 8 companies offering Sacubitril from 3 different countries.
Get in contact with the supplier of your choice:
- Shandong Octagon Chemicals Limited from China
- TIEFENBACHER API + Ingredients from Germany
- Zhejiang Hongyuan from China
- Lupin from India
- Zhejiang Tianyu from China
- Raks Pharma from India
- Mylan from India
- MSN Life Sciences from India
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