Tolbutamide | compare suppliers & send inquiries for free
Looking for Tolbutamide 64-77-7?
Do you want to know more about Tolbutamide? You can find a small explanation about it here. Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release.
Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces.
Check who is selling Tolbutamide in the overview above.
Tolbutamide manufacturers | traders | suppliers
We have 5 companies offering Tolbutamide from 4 different countries.
Get in contact with the supplier of your choice:
- TIEFENBACHER API + Ingredients from Germany
- Zhejiang Changming from China
- Dipharma Francis S.r.l. from Italy
- Quantum Drugs & Chemicals from India
- Kothari Phyto from India
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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