Find, compare & contact
Metformin hydrochloride (Metformin) API Manufacturers & Suppliers

Looking for Metformin API 657-24-9?

Description:

Here you will find a list of producers, manufacturers and distributors of Metformin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Metformin 

Synonyms:

Dimethylbiguanid , Haurymellin , Metformin , Metformina , Metformine , Metformine pamoate , Metforminum , Metformini , Metformin Hydrochloride  

Cas Number:

657-24-9 

DrugBank number:

DB00331 

Unique Ingredient Identifier:

9100L32L2N

Metformin is a type of Biguanides

Biguanides are a subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs) that play a significant role in the treatment of various medical conditions. These organic compounds exhibit antihyperglycemic properties, making them particularly important in the management of diabetes mellitus type 2.

The primary biguanide compound utilized in pharmaceutical formulations is metformin. Metformin works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. These mechanisms contribute to lower blood glucose levels and better glycemic control.

One of the key advantages of biguanides, particularly metformin, is their favorable safety profile. They are generally well-tolerated, with minimal risk of causing hypoglycemia compared to other antidiabetic medications. Biguanides also offer additional benefits such as cardiovascular protection and potential weight loss.

In addition to their role in diabetes management, biguanides are being investigated for their potential therapeutic applications in polycystic ovary syndrome (PCOS) and cancer treatment. Studies have shown promising results in reducing androgen levels and improving menstrual irregularities in PCOS patients. Furthermore, emerging research suggests that biguanides may have antineoplastic effects by targeting cancer cell metabolism and inhibiting tumor growth.

Overall, biguanides, with metformin being the most commonly prescribed, have become a cornerstone in the management of diabetes and are being explored for their potential in other medical conditions. Their favorable safety profile, efficacy in glycemic control, and additional health benefits make them an important class of pharmaceutical APIs in the modern healthcare landscape.

Metformin (Biguanides), classified under Anti-diabetics

Anti-diabetics, belonging to the pharmaceutical API (Active Pharmaceutical Ingredient) category, are a group of compounds designed to manage and treat diabetes mellitus, a chronic metabolic disorder characterized by high blood sugar levels. These medications play a vital role in controlling diabetes and preventing complications associated with the disease.

Anti-diabetics encompass a wide range of drug classes, including biguanides, sulfonylureas, thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists. Each class works through different mechanisms to regulate blood sugar levels and improve insulin sensitivity.

Biguanides, such as metformin, reduce glucose production by the liver and enhance insulin sensitivity in peripheral tissues. Sulfonylureas, like glipizide, stimulate insulin secretion from pancreatic beta cells. Thiazolidinediones, including pioglitazone, improve insulin sensitivity in muscle and adipose tissues. DPP-4 inhibitors, such as sitagliptin, increase insulin release and inhibit glucagon secretion. SGLT2 inhibitors, like dapagliflozin, decrease renal glucose reabsorption, leading to increased urinary glucose excretion. GLP-1 receptor agonists, such as exenatide, enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote satiety.

These anti-diabetic APIs serve as the foundational ingredients for the formulation of various oral tablets, capsules, and injectable medications used in the treatment of diabetes. By targeting different aspects of glucose regulation, they help patients achieve and maintain optimal blood sugar levels, thus reducing the risk of diabetic complications, such as cardiovascular disease, neuropathy, and nephropathy.

It is crucial for healthcare professionals to prescribe and administer these anti-diabetic medications appropriately, considering factors like the patient's medical history, co-existing conditions, and potential drug interactions. Regular monitoring of blood glucose levels and close medical supervision are necessary to ensure effective diabetes management.

In conclusion, anti-diabetics form a critical category of pharmaceutical APIs used for the treatment of diabetes. These compounds, encompassing various drug classes, work through distinct mechanisms to regulate blood sugar levels and improve insulin sensitivity. By facilitating glucose control, anti-diabetic APIs help mitigate the risk of complications associated with diabetes mellitus, ultimately promoting better health outcomes for patients.

• Chr. Olesen Group from Denmark, product country of origin China
• Xi'an ZB Biotech Co., Ltd from China, product country of origin China
• Rochem International, Inc. from United States, product country of origin United States
• LGM Pharma from United States, product country of origin World
• Sinoway industrial Co.,Ltd from China, product country of origin China
• Duchefa Farma B.V. from Netherlands, product country of origin India
• AXXO GmbH from Germany, product country of origin World
• Wanbury from India, product country of origin India
• THINQ Pharma from India, product country of origin India
• Abhilash Chemicals from India, product country of origin India
• Auro Laboratories from India, product country of origin India
• Aastrid International from India, product country of origin India
• G.C. Chemie Pharmie Ltd from India, product country of origin India
• Exemed Pharma from India, product country of origin India
• Unnati Pharmaceuticals Pvt Ltd from India, product country of origin India
• Danashmand from India, product country of origin India
• Harman Finochem from India, product country of origin India
• Aarambh Life Science from India, product country of origin India
• Shandong Fangxing Technology Development Co Ltd from China, product country of origin China
• Angels Pharma from India, product country of origin India
• Gennex Laboratories from India, product country of origin India
• TIEFENBACHER API + Ingredients from Germany, product country of origin Unknown
• Blue Circle Organics from India, product country of origin India
• Laurus Labs from India, product country of origin India
• USV from India, product country of origin India
• Shouguang Fukang from China, product country of origin Unknown
• Vistin Pharma from Norway, product country of origin Norway
• Lupin from India, product country of origin India
• Ipca Labs. from India, product country of origin India
• Sun Pharma from India, product country of origin India
• Yantai Dongcheng Bio. from China, product country of origin China

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

You can use the filters to find high-quality suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our FAQ page or use the chat box in the corner to get more information about Pharmaoffer.