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Mk-0431 (Sitagliptin) API Manufacturers
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Produced in:
Established in: 1987
MOQ: 1 kg
Employees: 50+
Passed ISO9001:2015 and SGS audit
Provide one-stop CDMO service from R&D to production
Specialized in APIs & Pharmaceutical Intermediates for 37 years
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Produced in:
Established in: 1951
MOQ: -
Employees: 455+
Largest Polish manufacturer of pharmaceuticals and a leader of the Polish pharmaceutical market.
FDA approved european manufcaturing facilities
Export APIs to more than 60 countries worldwide
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Producer
Produced in:
Established in: 1984
MOQ: -
Employees: 2000+
Vertically integrated company
Largest producer of Montelukast in the world
USFDA & WHO GMP approved API plants
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Producer
Produced in:
Established in: 2011
MOQ: 100 g
Employees: 10+
Fast Response and Good Communication
Willingness To Start From Small
Flexible Payment Terms
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Established for 17 years and a leading enterprise in China's API industry
Mature technology and advanced production equipment
Quality assurance and fast delivery
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Producer
Produced in:
Established in: 2019
MOQ: 1 kg
Employees: 10+
Focused on pharmaceutical industry
Reasonable price for the customers
Full service from R&D stage to commercial stage
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Producer
Produced in:
Established in: 2021
MOQ: -
Employees: 19
API, Intermediates, Building Blocks, Impurities, Amino acids and Peptides
Small quantity APIs to commercial scale
GMP and USFDA certification based on quantity, order, assignment.
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Producer
Produced in:
Established in: 2006
MOQ: 1 kg
Employees: 50+
Backward integration with key APIs
Current Good Manufacturing Practices (cGMP)
Unique reaction capabilities
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Produced in:
Established in: 1944
MOQ: -
Employees: 4,000
14 international API plant sites
Portfolio of 350+ APIs
Teva is among the world’s largest generic drug/API manufacturers
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Produced in:
Established in: 1984
MOQ: -
Employees: 21,650
Diverse portfolio of 180+APIs
1754+ DMF across global markets
1100+ patents filed, and more than 70 own patents granted
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Produced in:
Established in: 1995
MOQ: -
Employees: 10000
Fermentation technology Experts
Partnerships with 1200 pharma companies in 100+ countries
US FDA, EMA, COFEPRIES, ANVISA, PMDA accreditations
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Looking for Sitagliptin API 486460-32-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Sitagliptin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Sitagliptin
- Synonyms:
- MK-0431 , Sitagliptan , Sitagliptin phosphate , Sitagliptina , Sitagliptine , Sitagliptinum , Sitagliptin Phosphate Monohydrate , Sitagliptin Phosphate Anhydrous
- Cas Number:
- 486460-32-6
- DrugBank number:
- DB01261
- Unique Ingredient Identifier:
- QFP0P1DV7Z
About Sitagliptin
Do you want to know more about Sitagliptin? You can find a small explanation about it here. Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar1. Sitagliptin was granted FDA approval on October 20066.
Check who is selling Sitagliptin in the overview above.
Sitagliptin is a type of DPP4-Inhibitors
DPP4-Inhibitors, or dipeptidyl peptidase-4 inhibitors, belong to the subcategory of pharmaceutical active ingredients known for their therapeutic role in managing type 2 diabetes mellitus. These inhibitors work by targeting and inhibiting the action of the enzyme dipeptidyl peptidase-4 (DPP4) in the body.
DPP4 is responsible for breaking down incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By inhibiting DPP4, DPP4-Inhibitors enhance the levels and activity of these hormones. GLP-1 and GIP play crucial roles in regulating blood sugar levels by stimulating insulin release, inhibiting glucagon secretion, and slowing down gastric emptying.
The main advantage of DPP4-Inhibitors is their ability to improve glycemic control without the risk of hypoglycemia, which is a common side effect of some other diabetes medications. They are typically used as an adjunct therapy in combination with other antidiabetic agents, such as metformin, to achieve optimal glucose management.
Commonly prescribed DPP4-Inhibitors include sitagliptin, saxagliptin, linagliptin, and alogliptin. These drugs are available in oral tablet formulations, allowing for convenient administration. They have shown efficacy in lowering HbA1c levels and have a favorable safety profile.
It is important to note that DPP4-Inhibitors are not suitable for individuals with type 1 diabetes or those with a history of pancreatitis. As with any medication, there may be potential side effects, such as upper respiratory tract infections, headache, and gastrointestinal discomfort, which should be discussed with a healthcare professional.
In conclusion, DPP4-Inhibitors are a subcategory of pharmaceutical APIs that act by inhibiting the enzyme DPP4, thereby enhancing the effects of incretin hormones involved in glucose regulation. They are widely used in the management of type 2 diabetes mellitus, offering glycemic control benefits with a reduced risk of hypoglycemia.
Sitagliptin (DPP4-Inhibitors), classified under Anti-diabetics
Anti-diabetics, belonging to the pharmaceutical API (Active Pharmaceutical Ingredient) category, are a group of compounds designed to manage and treat diabetes mellitus, a chronic metabolic disorder characterized by high blood sugar levels. These medications play a vital role in controlling diabetes and preventing complications associated with the disease.
Anti-diabetics encompass a wide range of drug classes, including biguanides, sulfonylureas, thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists. Each class works through different mechanisms to regulate blood sugar levels and improve insulin sensitivity.
Biguanides, such as metformin, reduce glucose production by the liver and enhance insulin sensitivity in peripheral tissues. Sulfonylureas, like glipizide, stimulate insulin secretion from pancreatic beta cells. Thiazolidinediones, including pioglitazone, improve insulin sensitivity in muscle and adipose tissues. DPP-4 inhibitors, such as sitagliptin, increase insulin release and inhibit glucagon secretion. SGLT2 inhibitors, like dapagliflozin, decrease renal glucose reabsorption, leading to increased urinary glucose excretion. GLP-1 receptor agonists, such as exenatide, enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote satiety.
These anti-diabetic APIs serve as the foundational ingredients for the formulation of various oral tablets, capsules, and injectable medications used in the treatment of diabetes. By targeting different aspects of glucose regulation, they help patients achieve and maintain optimal blood sugar levels, thus reducing the risk of diabetic complications, such as cardiovascular disease, neuropathy, and nephropathy.
It is crucial for healthcare professionals to prescribe and administer these anti-diabetic medications appropriately, considering factors like the patient's medical history, co-existing conditions, and potential drug interactions. Regular monitoring of blood glucose levels and close medical supervision are necessary to ensure effective diabetes management.
In conclusion, anti-diabetics form a critical category of pharmaceutical APIs used for the treatment of diabetes. These compounds, encompassing various drug classes, work through distinct mechanisms to regulate blood sugar levels and improve insulin sensitivity. By facilitating glucose control, anti-diabetic APIs help mitigate the risk of complications associated with diabetes mellitus, ultimately promoting better health outcomes for patients.
Sitagliptin manufacturers | traders | suppliers
We have 33 companies offering Sitagliptin produced in 7 different countries.
Get in contact with the supplier of your choice:
- Sinoway industrial Co.,Ltd from China, product country of origin China
- Polpharma from Poland, product country of origin Poland
- Morepen Laboratories Ltd. from India, product country of origin India
- Shandong Octagon Chemicals Limited from China, product country of origin China
- Xi'an ZB Biotech Co., Ltd from China, product country of origin China
- Apino Pharma Co., Ltd. from China, product country of origin China
- SETV Global from India, product country of origin India
- Zhejiang Changming from China, product country of origin China
- Honour Lab from India, product country of origin India
- Humble Healthcaare from India, product country of origin India
- Fuxing Long Rui Pharma from China, product country of origin China
- Zhejiang Apeloa Tospo-Jiayuan from China, product country of origin China
- KRKA from Slovenia, product country of origin Slovenia
- Signa from Mexico, product country of origin Mexico
- Solfyn International LLP from India, product country of origin China
- Acura Labs from India, product country of origin India
- Tianjin Minxiang from China, product country of origin China
- Teva API from Israel, product country of origin Unknown
- Sintenovo from Spain, product country of origin Spain
- Hikal from India, product country of origin India
- Beijing Huikang Boyuan from China, product country of origin China
- Dr. Reddy's from India, product country of origin India
- Torrent Pharma from India, product country of origin India
- Biocon from India, product country of origin India
- HEC Pharm from Germany, product country of origin China
- Lupin from India, product country of origin India
- Sun Pharma from India, product country of origin India
- MSN Pharma from India, product country of origin India
- Jubilant Generics from India, product country of origin India
- Divis Labs. from India, product country of origin India
- Mylan from India, product country of origin India
- Shaoxing Hantai Pharma from China, product country of origin China
- Moehs from Spain, product country of origin Spain
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