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Some technical information about this product: Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison (ZE) Syndrome. It can also be found in quadruple regimens for the treatment of H. pylori infections along with other antibiotics including Amoxicillin, Clarithromycin, and Metronidazole, for example Its efficacy is considered similar to other medications within the PPI class including Omeprazole, Pantoprazole, Lansoprazole, Dexlansoprazole, and Rabeprazole. Esomeprazole is the s-isomer of Omeprazole, which is a racemate of the S- and R-enantiomer.
Esomeprazole has been shown to inhibit acid secretion to a similar extent as Omeprazole, without any significant differences between the two compounds in vitro. Esomeprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cells. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. As the binding of esomeprazole to the (H+, K+)-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, esomeprazole's duration of antisecretory effect persists longer than 24 hours.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Esomeprazole manufacturers | traders | suppliers
We have 38 companies offering Esomeprazole from 7 different countries.
Get in contact with the supplier of your choice:
- JINLAN Pharm-Drugs Technology Co., Ltd. from China
- Hetero Drugs from India
- Lupin from India
- Morepen Laboratories Limited from India
- Minakem from France
- Sterile India from India
- Metrochem API from India
- Lee Pharma from India
- Aurobindo from India
- Emcure Pharma from India
- Menovo from China
- Fabbrica Italiana Sintetici (FIS) from Italy
- Mylan from India
- Dr. Reddy's from India
- Zhejiang Changming from China
- Glenmark Pharma from India
- PCAS from France
- Sun Pharma from India
- Jubilant Generics from India
- Esteve Quimica from Spain
- Macleods Pharma from India
- MSN Life Sciences from India
- Torrent Pharma from India
- Cipla from India
- HEC Pharm from Germany
- Sandoz from Austria
- Shouguang Fukang from China
- Mac Chem Products from India
- Alkem Labs. from India
- KRKA from Slovenia
- Jiangsu Zhongbang from China
- Zhejiang Neo-Dankong from China
- Zhejiang Huayi from China
- Zhejiang Yongtai Pharma from China
- Rajasthan Antibiotics from India
- Cadila Healthcare from India
- Ehfield Co.,Ltd from China
- Laboratorios Dr Esteve from Spain
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