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Looking for Lovastatin API 75330-75-5?

Description:: Here you will find a list of producers, manufacturers and distributors of Lovastatin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:: Lovastatin
Synonyms:: methylcompactin , LOVASTATIN , Lovastatina , Lovastatine , Lovastatinum , Mevacor , Mevinolin , MK-803 , ML-530b
Cas Number:: 75330-75-5
DrugBank number:: DB00227
Unique Ingredient Identifier:: 9LHU78OQFD

About Lovastatin

You can find a short description about Lovastatin here. Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as bad cholesterol), and very low-density lipoprotein (VLDL).

Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes.

You can find more info about this product by clicking on the DB ID above.

Good Manufacturing Practices

Active pharmaceutical ingredients are made in GMP-certified manufacturing facilities. GMP stands for Good Manufacturing Practices and is the main standard in the pharmaceutical industry. cGMP or Current GMP means that the company complies with the most recent requirements/version of GMP. The WHO has its own guideline for GMP, the World Health Organization or WHO GMP. The authority that has audited the company can also be from a country like China (Chinese GMP) or from the EU (EU GMP), every authority has different GMP requirements.

Certificate of Analysis

A CoA is a document issued by a companies’ QA/QC-department that confirms that a product meets its product specification and is part of the quality control of a product batch. The CoA commonly contains results obtained from laboratory tests of an individual batch of a product. There are different international standards to which a product can be tested, for example: Ph. Eur. | EP – (European Pharmacopoeia) USP – (United States Pharmacopeia)

Certificate of Suitability

CEP (also known as COS) is a certificate that proves that qualifies to the relevant monograph of the European Pharmacopoeia. It links the monograph in the Ph.Eur. to the API itself. A CEP is submitted by the manufacturer as part of the market authorization process, and they will become the CEP holder of the document. Being a European certificate, the CEP is granted by the EDQM but is recognized by other countries or institutes such as the FDA in the US. Furthermore, just like the DMF, the data as submitted in the CEP is handled strictly confidential and provides a centralized system recognized by many countries.

Drug Master File

A drug master file is a document submitted to governmental bodies that contains all details of the manufacturing process of an API or medicine. This includes information on chemical properties, the facilities used, the processes used, details on packaging, storage, et cetera. In order to protect the intellectual property of the manufacturer, this document is confidential. Countries may have different guidance compared to other countries, that’s why different types of DMF exist. For example, you may have a US DMF, ASMF (formally known as EDMF), Japanese DMF, Chinese DMF, et cetera.

Lovastatin is a type of Statins

Statins are a widely prescribed class of pharmaceutical active ingredients (APIs) used for the treatment of high cholesterol and prevention of cardiovascular diseases. These medications work by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in the production of cholesterol in the liver.

Statins are categorized as lipid-lowering agents and are highly effective in reducing levels of low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol. By decreasing LDL cholesterol, statins help to prevent the formation of plaque in the arteries, reducing the risk of heart attacks and strokes.

There are several popular statins available on the market, including atorvastatin, simvastatin, rosuvastatin, and pravastatin. Each statin differs in terms of potency, dosing, and potential drug interactions, allowing healthcare professionals to select the most appropriate option for individual patients.

Statins are typically taken orally in the form of tablets or capsules and are available in different strengths. The dosage is determined by various factors such as the patient's cholesterol levels, cardiovascular risk, and response to treatment.

While statins are generally well-tolerated, they can have side effects such as muscle pain, liver dysfunction, and gastrointestinal disturbances. However, these side effects are relatively rare and are outweighed by the significant cardiovascular benefits of statin therapy.

In conclusion, statins are a vital subclass of pharmaceutical APIs used for managing high cholesterol and reducing the risk of cardiovascular diseases. They effectively lower LDL cholesterol levels and are an essential component of treatment plans for individuals with hyperlipidemia or a high risk of heart disease.

Lovastatin (Statins), classified under Lipid-lowering agents

Lipid-lowering agents are a category of pharmaceutical active ingredients (APIs) that are widely used in the treatment of hyperlipidemia, a condition characterized by elevated levels of lipids (such as cholesterol and triglycerides) in the blood. These agents play a crucial role in managing lipid abnormalities and reducing the risk of cardiovascular diseases.

One of the most commonly prescribed lipid-lowering agents is statins. Statins work by inhibiting an enzyme called HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. By blocking this enzyme, statins effectively lower cholesterol levels in the bloodstream.

Another class of lipid-lowering agents is fibric acid derivatives, which primarily target triglyceride levels. These agents activate a nuclear receptor known as PPAR-alpha, which regulates lipid metabolism. By activating PPAR-alpha, fibric acid derivatives enhance the breakdown of triglycerides and increase the elimination of fatty acids from the bloodstream.

Additionally, bile acid sequestrants are often used as lipid-lowering agents. These agents bind to bile acids in the intestine, preventing their reabsorption. As a result, the liver utilizes more cholesterol to produce new bile acids, leading to a decrease in circulating cholesterol levels.

Lipid-lowering agents are available in various formulations, including tablets, capsules, and suspensions, allowing for convenient administration. They are usually prescribed alongside lifestyle modifications, such as dietary changes and regular exercise, to optimize the management of hyperlipidemia.

It is important to note that the use of lipid-lowering agents should be under the supervision of a healthcare professional, as they may have potential side effects and interactions with other medications. Proper monitoring of lipid levels and regular follow-up visits are essential for ensuring the effectiveness and safety of these pharmaceutical agents.

Lovastatin manufacturers | traders | suppliers

We have 11 companies offering Lovastatin produced in 3 different countries.

Get in contact with the supplier of your choice:

Shandong Octagon Chemicals Limited from China, product country of origin China
Krebs Biochem from India, product country of origin India
Zhejiang Hisun Pharma from China, product country of origin China
Teva API from Israel, product country of origin Unknown
Biocon from India, product country of origin India
Fuan Pharma Group (Yantai Justaware) from China, product country of origin China
Lupin from India, product country of origin India
Yantai Justaware from China, product country of origin China
Sterling Biotech from India, product country of origin India
Aquatic Remedies Pvt Ltd from India, product country of origin India
Shaoxing Hantai Pharma from China, product country of origin China

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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Lovastatin API Manufacturers with CEP, CoA, DMF, GMP

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