Valsartan | compare suppliers & send inquiries for free
Looking for Valsartan 137862-53-4?
- API | Excipient name:
- Valsartan
- Synonyms:
- Diovan, Valsartan Process II
- Cas Number:
- 137862-53-4
- DrugBank number:
- DB00177
- Unique Ingredient Identifier:
- 80M03YXJ7I
About Valsartan
Want to know more about Valsartan? Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, olmesartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone and ADH, cardiac stimulation, and renal reabsorption of sodium, among others. Overall, valsartan's physiologic effects lead to reduced blood pressure, lower aldosterone levels, reduced cardiac activity, and increased excretion of sodium. Valsartan also affects the renin-angiotensin aldosterone system (RAAS), which plays an important role in hemostasis and regulation of kidney, vascular, and cardiac functions.
Pharmacological blockade of RAAS via AT1 receptor blockade inhibits negative regulatory feedback within RAAS, which is a contributing factor to the pathogenesis and progression of cardiovascular disease, heart failure, and renal disease. In particular, heart failure is associated with chronic activation of RAAS, leading to inappropriate fluid retention, vasoconstriction, and ultimately a further decline in left ventricular function. ARBs have been shown to have a protective effect on the heart by improving cardiac function, reducing afterload, increasing cardiac output and preventing ventricular hypertrophy and remodelling.
Check who is selling Valsartan in the overview above.
Valsartan manufacturers | traders | suppliers
We have 40 companies offering Valsartan from 7 different countries.
Get in contact with the supplier of your choice:
- Shandong Octagon Chemicals Limited from China
- TIEFENBACHER API + Ingredients from Germany
- Chunghwa Chemical Synthesis & Biotech Co., Ltd. from Taiwan
- Aurobindo from India
- Lupin from India
- Divis Labs. from India
- Sun Pharma from India
- Maithili Life Sciences from India
- Zhejiang Tianyu from China
- Mylan from India
- Dr. Reddy's from India
- Menovo from China
- Granules India from India
- Harman Finochem from India
- Zhejiang Changming from China
- Cadila Pharma from India
- Zhejiang Hisun Pharma from China
- Shaoxing Hantai Pharma from China
- R. L. Fine Chem from India
- Hetero Labs from India
- Jubilant Generics from India
- Ipca Labs. from India
- Alembic Pharma from India
- Macleods Pharma from India
- Zhejiang Huahai Pharma from China
- Teva from Israel
- Kolon Life Science from South Korea
- Laurus Labs from India
- MSN Life Sciences from India
- Teva Pharma ind. from Israel
- Cadila Healthcare from India
- Zhuhai Rundu from China
- Teva India from Israel
- Signa from Mexico
- Chromo Labs. from India
- KRKA from Slovenia
- Kyowa Pharma Chem. from Japan
- Daewoong Bio from South Korea
- Shin Poong Pharm from South Korea
- Sumitomo Chemical from Japan
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