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Osaka Synthetic Chemical Lab
Looking for Ifenprodil 23210-56-2?
It's time for some technical information for the ones who understand chemistry: N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function NMDARs are heterotetramers that typically involve a dimer of dimers of both GluN1 and GluN2A-D subunits, with each subunit itself composed of an N-terminal domain (NTD), a ligand-binding domain (LBD), a transmembrane domain, and a C-terminal cytoplasmic domain. Binding at the LBD of the agonists glycine (or D-serine) to the GluN1 subunits and of glutamate to the GluN2 subunits is a regulatory mechanism for channel activation. In addition, allosteric modulators are known to bind at the NTDs and form another layer of regulation One such allosteric regulator is ifenprodil, which was first shown to bind the NMDARs in the 1990s, and specifically to those NMDARs containing the GluN2B subunit. Further studies elucidated that ifenprodil binds strongly at the inter-subunit interface of adjacent GluN1 and GluN2B NTDs, where it acts as a non-competitive antagonist Although ifenprodil has received considerable interest in its potential neuromodulatory activities in psychiatric conditions.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Ifenprodil manufacturers | traders | suppliers
We have 2 companies offering Ifenprodil from 1 different countries.
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- Osaka Synthetic Chemical Lab from Japan
- Iwaki Seiyaku from Japan
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