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Fumaric acid (Dimethyl fumarate) API Manufacturers
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Produced in:
Established in: 1989
MOQ: -
Employees: 5000+
6 production facilities approved by USFDA, AGES-Austria, PMDA, WHO
R&D Centers with capabilities of ANDAs, DMFs and NDDS
462+ patents filed for drug substances and polymorphs
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Produced in:
Established in: 1922
MOQ: -
Employees: 2400+
Leading Japanese manufacturer with over 100 years of history
Offices in Japan, US, China, and Germany, factory in Japan
Offer GMP complied products and CRO service
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Producer
Produced in:
Established in: 2013
MOQ: 1 kg
Employees: 25+
ISO9001 certified
Drug R&D center (in Hangzhou)
From lab scale (mg/g) to commercial scale (kgs/tons)
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Produced in:
Established in: 2005
MOQ: -
Employees: 200+
Portfolio of over 2,000 APIs
Precise quality control
End-to-end global regulatory support
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Produced in:
Established in: 1984
MOQ: -
Employees: 21,650
Diverse portfolio of 180+APIs
1754+ DMF across global markets
1100+ patents filed, and more than 70 own patents granted
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Producer
Produced in:
Established in: 1975
MOQ: 50 kg
Employees: 80+
State-of-the-art CMO & CRO facility
APIs for human & veterinary medicines
Development, analysing and production of APIs
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Produced in:
Established in: 1994
MOQ: -
Employees: 4,000
All our 5 plants are top notch and FDA approved
We are a backwards integrated company
We have received 24 CEP’s and 27 USDMF’s
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Producer
Produced in:
Established in: 1944
MOQ: -
Employees: 4,000
14 international API plant sites
Portfolio of 350+ APIs
Teva is among the world’s largest generic drug/API manufacturers
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Looking for Dimethyl fumarate API 624-49-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Dimethyl fumarate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Dimethyl fumarate
- Synonyms:
- dimethyl (E) butenedioate , Fumaric acid , dimethyl ester , Tecfidera , trans-1 , 2-Ethylenedicarboxylic acid dimethyl ester , trans-Butenedioic acid dimethyl ester
- Cas Number:
- 624-49-7
- DrugBank number:
- DB08908
- Unique Ingredient Identifier:
- FO2303MNI2
About Dimethyl fumarate
So, what does it do? Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
Check who is selling Dimethyl fumarate in the overview above.
Dimethyl fumarate is a type of Immunosuppressants
Immunosuppressants are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in medical treatments. These substances are designed to suppress or weaken the immune system's response, making them invaluable in various therapeutic applications.
Immunosuppressants find extensive use in the management of autoimmune diseases, organ transplantation, and the prevention of rejection reactions. By modulating the immune system's activity, these APIs help control excessive immune responses that can lead to tissue damage and chronic inflammation.
There are different classes of immunosuppressants, including corticosteroids, calcineurin inhibitors, antimetabolites, and biologics. Each class targets specific immune pathways to achieve the desired therapeutic effect. Corticosteroids, for instance, are known for their potent anti-inflammatory properties, making them effective in managing conditions such as rheumatoid arthritis and asthma.
Calcineurin inhibitors like cyclosporine and tacrolimus act by inhibiting the activity of calcineurin, a protein involved in immune cell activation. These drugs are commonly used in organ transplantation to prevent the immune system from attacking the transplanted organ.
Antimetabolites interfere with DNA synthesis and cell proliferation, thereby dampening immune responses. They are often prescribed for conditions like psoriasis and rheumatoid arthritis.
Biologic immunosuppressants, such as monoclonal antibodies, target specific immune cells or molecules involved in the disease process. They have revolutionized the treatment of autoimmune diseases like rheumatoid arthritis, Crohn's disease, and psoriasis.
Immunosuppressants require careful administration and monitoring due to their potential side effects and interactions with other medications. Close collaboration between healthcare professionals, pharmacists, and patients is essential to ensure the safe and effective use of these APIs in various therapeutic settings.
Overall, immunosuppressants represent a critical category of pharmaceutical APIs that significantly contribute to improving patients' quality of life by controlling the immune system's activity and managing various autoimmune conditions and transplantation outcomes.
Dimethyl fumarate (Immunosuppressants), classified under Immunomodulators
Immunomodulators, a category of pharmaceutical active pharmaceutical ingredients (APIs), are substances that help regulate and modify the immune response of an individual. These compounds play a crucial role in treating various immune-related disorders and diseases. Immunomodulators work by either enhancing or suppressing the immune system, depending on the specific condition being treated.
Immunomodulators are used in the treatment of autoimmune disorders, such as rheumatoid arthritis, multiple sclerosis, and psoriasis. By suppressing the immune system, these APIs help reduce the overactive immune response associated with these conditions, thereby alleviating symptoms and preventing further damage to the body's tissues.
On the other hand, immunomodulators are also employed to boost the immune system in cases of immunodeficiency disorders. These APIs stimulate the immune response, enabling the body to better fight off infections and diseases. Additionally, immunomodulators are utilized in the prevention and treatment of organ transplant rejection, where they help modulate the immune system to accept the transplanted organ.
The development and production of immunomodulators require rigorous testing and quality control to ensure their safety and efficacy. Pharmaceutical companies carefully formulate these APIs into various dosage forms, including tablets, capsules, injections, and topical preparations, to cater to different patient needs.
In summary, immunomodulators form a vital category of pharmaceutical APIs that regulate and modify the immune system. With their ability to modulate immune responses, these compounds contribute significantly to the management and treatment of various immune-related disorders and diseases, improving the quality of life for many patients.
Dimethyl fumarate manufacturers | traders | suppliers
We have 26 companies offering Dimethyl fumarate produced in 8 different countries.
Get in contact with the supplier of your choice:
- Shilpa Medicare Ltd from India, product country of origin India
- Fujifilm Wako Pure Chemical Corporation from Japan, product country of origin Japan
- Senova Technology Co., Ltd. from China, product country of origin China
- LGM Pharma from United States, product country of origin World
- PLIVA from Czech Republic, product country of origin Croatia
- Chinoin from Hungary, product country of origin Hungary
- Raks Pharma from India, product country of origin India
- Dr. Reddy's from India, product country of origin India
- Sionc Pharma from India, product country of origin India
- Laboratorium Ofichem B.V. from Netherlands, product country of origin Netherlands
- Alkem Labs. from India, product country of origin India
- Torrent Pharma from India, product country of origin India
- Arevipharma from Germany, product country of origin Unknown
- Unichem Labs. from India, product country of origin India
- Natco Pharma from India, product country of origin India
- Intas Pharma from United Kingdom, product country of origin Unknown
- Vasudha Pharma Chem Ltd. from India, product country of origin India
- Teva API from Israel, product country of origin Unknown
- Yabao Pharma from China, product country of origin China
- Honour Lab from India, product country of origin India
- Optimus Drugs Pvt Ltd from India, product country of origin India
- Biophore India from India, product country of origin India
- Mylan from India, product country of origin India
- Sun Pharma from India, product country of origin India
- MSN Organics from India, product country of origin India
- Micro Labs from India, product country of origin India
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